腹腔灌注和全身热疗治疗非根治术后晚期胃癌56例临床分析

Observation on intraperitoneal chemotherapy combined with whole body hyperthermia after palliative surgery for advanced gastric carcinoma

目的探讨腹腔灌注和全身热疗治疗非根治术后晚期胃癌的疗效。方法56例非根治术后晚期胃癌患者随机分为两组:对照组和热疗组。每组28例,对照组予腹腔灌注化疗+全身化疗;热疗组在对照组基础上,腹腔灌注后予全身热疗。结果热疗组的2年生存率明显高于对照组(P<0.05)。两组间毒副作用差异无显著性。结论腹腔灌注和全身热疗治疗非根治术后晚期胃癌是一种有效的治疗手段。

【Objective】To evaluate the curative effect of intraperitoneal chemotherapy combined with whole body hyperthermia after palliative surgery for advanced gastric carcinoma.【Methods】 A total of 56 patients with advanced gastric cancer who underwent non-radical surgery were randomly divided into two groups（n=28 in each group）,i.e.control group and thermotherapy group.The control group was treated with intraperitoneal chemotherapy and body chemotherapy while the thermotherapy group was treated with whole body hyperthermia after intraperi-toneal chemotherapy,and the remaining treatments were the same with the control group.【Results】The rate of 2 year survival had significant difference between the two groups,it was higher in the thermotherapy group than in the control group（P〈0.05）,and the side effects between the two groups had no significant difference.【Conclusion】It is a useful method to treat patients who have accepted palliative surgery for advanced gastric carcinoma with intraperitoneal chemotherapy combined with whole body hyperthermia.