绿激光结合THP即刻膀胱灌注治疗腺性膀胱炎(附26例报告)

Bladder instillation of Pirarubicin shortly combined with GPV in treatment of cystitis glandularis (a report of 26 cases)

目的研究绿激光结合THP(吡柔比星)即刻膀胱灌注治疗腺性膀胱炎的安全性和可靠性。方法应用绿激光经尿道膀胱镜下对26例腺性膀胱炎患者进行选择性光汽化治疗,并行THP即刻膀胱灌注。结果26例腺性膀胱炎患者均一次直接汽化成功,汽化深达浅肌层,无出血、闭孔神经反射、膀胱穿孔,无水、THP中毒发生,术后26例患者均留置尿管2～3d,未行膀胱冲洗。术后3～36个月行膀胱镜检查,见膀胱黏膜已修复完整,未见膀胱炎症存在,无复发,选择性复查12例膀胱组织活检,病理显示:未见Brunn's巢,26例腺性膀胱炎患者术后疗效满意。结论绿激光结合THP即刻膀胱灌注治疗腺性膀胱炎是一种安全有效的微创疗法。

【Objective】To research the security and reliability of bladder instillation of Pirarubicin（THP） shortly combining with GPV in treatment of cystitis glandularis. 【Methods】Twenty-six cases with cystitis glandularis were treated with GPV, and bladder instillation of Pirarubicin was applied shortly. 【Results】All 26 cases with cystitis glandularis were cured successfully. There was no bleeding, obturator nerve reflex, bladder perforation, TURP syndrome or THP toxicosis. Catheters were indwelled for 2-3 days after operation without washing bladders. With the examinination of urethral cystoscope after 3-36 months, bladder mucosa was found to have restored and there was no cystitis or relapse. The pathological re-examination of bladder tissue in 12 cases showed no Brunn＇s nests. All 26 cases were satisfied with the treatment. 【Conclusion】It is secure and efficient to apply bladder instillation of THP shortly combined with GPV in treatment of cystitis glandularis.