摘要
将镁锌合金植入大鼠盲肠,研究其对肝肾功能电解质的影响。取SD大鼠72只,以随机数字法分为镁合金组、纯钛组和假手术组,每组24只。镁合金组在盲肠末端切口周围包埋长约5mm×1mm×1mm的镁锌合金条,纯钛组植入相同尺寸的医用纯钛条,假手术组仅做缝合,并于术前和术后检测血清肝肾功能电解质。结果表明,各组肝肾功能电解质的差异无统计学意义(P>0.05),镁锌合金植入大鼠盲肠后对其肝肾功能电解质无明显影响,初步证实了镁锌合金的生物安全性。
The biodegradable Mg-Zn alloy samples are implanted in cecum to study the influence on rat hepatic and renal function electrolytes. 72 SD rats are randomly divided into magnesium alloy group, medical titanium group and the sham-operated group, and each group has 24 SD rats. Then magnesium-zinc alloy samples with the dimension of 5mm×1mm× 1mm are embeded in the cecum incision. The same surgical procedure is done in the medical titanium group, and just suture in the sham-operation group. Prior to and after operation the hepatic and renal function electrolyte of each group are examined. The results show that there are no significant differences in the blood hepatic and renal function electrolytes among the magnesium alloy group, the titanium group and the sham-operated group（P〉0. 05）. Mg-Zn alloy after implantation in rat cecum has no obvious effects on the hepatic and renal function electrolytes, which is used to initially confirm the biological security of the Mg-Zn alloy in the intestine field.
出处
《材料导报》
EI
CAS
CSCD
北大核心
2010年第24期42-44,共3页
Materials Reports
基金
国家自然科学基金资助项目(30901422)
关键词
可降解镁合金
大鼠盲肠
肝肾功能
电解质
biodegradable Mg-Zn alloy, rat cecum, hepatic and renal function, electrolytes
