3330例药品不良反应报告分析

ANALYSIS OF 3330 ADVERSE DRUG REACTIONS IN YAAN CITY

目的:探讨我市药品不良反应(ADR)发生的一般规律和特点,为临床合理用药提供参考。方法:收集四川省药品不良反应监测中心雅安分中心数据,对我市2005年至2009年3330例报告进行分类统计、分析。结果:本组不良反应病例多发生于30～39岁和>60岁年龄组,女性高于男性;3330例ADR中,抗感染药物引起的ADR占总比例的57.48%(2072例),中药制剂占总例数的13.12%(473例)。ADR表现以皮肤损伤最为常见,占总比例的41.62%(1386例);较为严重的ADR占总例数的2.64%(88例);静脉给药引发的ADR最多,占总例数的69.82%(2325例)。结论:应全方位加强ADR监测工作,以减少和避免不良反应发生。

Objective： To study the occurrence of adverse drug reactions（ADR） in Yaan city for references of rational use of drugs in the clinic.Methods： 3330 cases of ADR reported in Yaan city collected by ADR monitoring center in 20052009 were classified and analyzed statistically.Results：The ADR occured more in 3039 and 〉60 age groups,and more in female than in male.Of the 3330 ADR cases,2072 cases were resulted from antibiotic drugs which accounted for 57.48%,473 cases were resulted from traditional Chinese drug preparations which accounted for 13.12%;ADR most commonly manifested itself in the injury of skin,which accounted for 42.14%（1386 cases）,next the damage of digestive system and circulation system;there were 88（2.64%） comparatively serious ADR cases among which;most cases were resulted from iv which accounted for 70.30%（2325 cases） of the total.Conclusion：ADR monitoring work should be deployed so as to lessen and avoid the occurrence of ADR.