2型糖尿病患者冠状动脉粥样硬化斑块的观察

Assessment of coronary atherosclerotic plaques in type 2 diabetic patients

对262例有胸痛等症状而行64排螺旋CT冠状动脉成像检查患者的临床资料进行回顾性分析。其中有糖尿病者79例，无糖尿病者183例。糖尿病者出现斑块及发生狭窄节段数、非梗阻性狭窄节段数、非钙化斑块及钙化斑块节段数均多于无糖尿病者（P值分别为〈0．01，〈0．05，〈0．01和〈0．05），混合斑块节段数比较差异无统计学意义。提示2型糖尿病患者冠状动脉粥样硬化病变程度重、非梗阻性狭窄节段数多，类型以非钙化斑块及钙化斑块为主。

The study intended to evaluate the atherosclerotic plaque burden and composition among symptomatic patients with and without type 2 diabetes mellitus. Total 262 symptomatic patients, including 79 with type 2 diabetes and 185 without, underwent multislice computed tomography coronary augiography. The extent of coronary atherosclerosis and 3 plaque types were studied. Patients with diabetes showed more diseased coronary segments （ P 〈 0. 01 ） and more nonobstructive segments （ P 〈 0. 05 ） than non diabetic patients. Compared to non diabetic patients, diabetic patients had a higher number of coronary segments with non-calcified （ P = 0. 005 ） and calcified （ P = 0. 016 ） plaques, but not for mixed plaques. The results indicate that type 2 diabetic patients have higher coronary plaque burden.