长托宁与阿托品作为无痛人工流产手术术前用药的比较

Comparision of penehyclidine chloride and atropine as premedication of painless induced abortion

目的比较长托宁与阿托品做为无痛人工流产手术前用药的临床效果,为临床用药提供依据。方法 80例行人工流产手术患者随机分为两组,每组40例。依术前用药分为组Ⅰ为长托宁组,长托宁0·5mg;组Ⅱ为阿托品组0·5mg。采用丙泊酚和舒芬太尼麻醉。观察患者HR、MAP、口干程度、术中扩宫颈时宫颈松弛度、术中人流综合征及术中术后并发症。结果长托宁组患者HR、MAP无有明显变化,阿托品组HR、MAP给药后及术中明显升高。长托宁组口干程度较阿托品组明显,而扩宫颈时宫颈松弛长托宁组明显好于阿托品组。长托宁组的术后并发症明显少于阿托品组。结论长托宁用于人工流产手术术前用药临床效果明显好于阿托品。

Objective To compare the effects of penehyclidine hydrochloride and atropine as premedication of painless induced abortion.Methods Eighty patients with early pregnance,ASAⅠ-Ⅱ,scheduled for painless induced abortion were randomly double-blindly assigned into two groups（n=40）：group Ⅰ（the penehyclidine hydrochloride group） received penehyclidine hydrochloride 05 mg as premedication,and group Ⅱ（the atropine group） received atropine 05 mg.Intravenous anesthesia was administered with propofol and sufentanyl.HR、MAP、the extent of dry mouth,and the relaxing extent of cervix uteri were observed and recorded.Results HR and MAP significant in group Ⅰ changed lessly,and HR、MAP in group Ⅱ changed significantly.The extents of dry mouth were more in group Ⅰ,and the relaxing extent of cervix uteri was significantly higher in group Ⅰ than that in group Ⅱ.Conclusion penehyclidine hydrochloride is much more effective and safe than atropine as premedication to painless induced abortion.