阿替普酶静脉溶栓治疗急性脑梗死的疗效

Clinical effect of alteplase on acute cerebral inflarction

目的观察阿替普酶对急性脑梗死的临床疗效。方法将2009年9月～2010年3月笔者所在科收治的251例急性脑梗死患者中符合静脉溶栓时间窗的30例随机分为治疗组与对照组。静脉溶栓治疗组15例，应用阿替普酶静脉溶栓治疗；对照组15例，采用常规药物治疗。两组于治疗前、后不同时间进行NIHSS评分的测定。结果溶栓组与对照组的疗效存在显著差异，溶栓组NIHSS评分减少程度高于对照组（均P〈0．05）。结论阿替普酶静脉溶栓治疗急性脑梗死有较好的疗效，并能显著改善神经功能缺损症状，

Objective To study the clinical effect of alteplase on acute cerebral inflarction. Methods There were 251 eases of patients with acute cerebral infarction from September 2009 to March 2010 in our department. 30 cases of acute cerebral inflarction which were in accord with intravenous thrombolysis time window were randomly divided into treatment group and control group, 15 eases of each. Intravenous thrombolytic therapy with 15 cases, application for aheplase intravenous thrombolytic therapy ; the conventional group 15 cases, using conventional treatments. Both groups were measured NIHSS score in different time before and after treatment. Resuls The reducing degree of NIHSS score was significantly higher in the treatment group than in the control group （ P 〈 0. 05 ）. Conclusion Intravenous thrombolytic therapy u sing alteplase in patients with acute cerebral infarction has good curative effect, and can significantly improve neurologic deficits symptoms.