血清骨桥蛋白在慢性阻塞性肺疾病患者中的表达及临床意义

LEVEL OF SERUM OSTEOPONTIN AND ITS CLINICAL SIGNIFICANCE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

目的探讨血清骨桥蛋白(osteopontin,OPN)水平与慢性阻塞性肺疾病(COPD)的关系。方法 COPD急性加重期患者26例作为A组,平均年龄(62.32±4.11)岁;COPD缓解期患者23例作为B组,平均年龄(61.38±4.32)岁;C组18例,为年龄、性别匹配的吸烟者对照组;D组18例,为年龄、性别匹配的不吸烟者对照组,检测各组血清骨桥蛋白水平并比较分析。结果 A组患者血清OPN水平最高,较其他三组比较,差异具有统计学意义(P<0.01);B组患者血清OPN水平次之,较C,D组比较,差异有统计学意义(P<0.01);D组血清OPN水平最低,较C组比较,差异有统计学意义(P<0.05)。结论血清OPN水平可能是反应COPD病情变化的早期指标,并且与病情的严重程度有关。

Objective To study the relation of osteopontin in serum of patients to chronic obstructive pulmonary disease.Methods The serum specimens were collected from four groups of subjects：group A（with COPD acute exacerbation,n=26）,aged 62.32±4.11years;group B（with COPD catabasis,n=23）,aged 61.38±4.32years;group C（smokers with age and sex matched,n=18）;group D（non-smokers with age and sex matched,n=18）.And then the level of serum osteopontin was analyzed in all subjects.Results Comparing with other three groups,the level of serum osteopontin in group A was significantly higher（P〈0.01）;which in group B was significantly higher than those of group C and D（P〈0.01）;Comparing with group C,level of serum osteopontin in D group was significantly lower,moreover,the differences of those were statistically significant（P〈0.05）.Conclusions Level of serum osteopontin may be regarded as a early diagnoses indicator of COPD,and relevant to severity of patient＇s condition.