摘要
目的:探讨心脑通络液对局灶性脑缺血大鼠脑组织白介素8(IL-8)、胰岛素样生长因子1(IGF-1)含量的影响。方法:采用线栓法复制局灶性脑缺血大鼠模型,以步长脑心通为对照,于脑缺血6h、12h、24h以及48h动态观察心脑通络液对局灶性脑缺血大鼠脑组织IL-8、IGF-1含量的影响。结果:脑梗塞6h,模型组脑组织IL-8含量开始增加,48h达高峰,均有显著性差异(P<0.01);各治疗组与同点模型组比较,脑组织IL-8含量均有不同程度降低,除6h对照组、低剂量组,12h对照组、低剂量组外,均有显著性差异(P<0.01或P<0.05);脑梗塞6h,模型组脑组织IGF-1含量开始增加,48h达高峰,均有显著性差异(P<0.01);各治疗组与同点模型组比较,脑组织IGF-1含量均有不同程度升高,均有显著性差异(P<0.01)。结论:心脑通络液可降低局灶性脑缺血大鼠急性期脑组织IL-8的含量,减轻缺血时炎性损伤;同时可升高局灶性脑缺血大鼠急性期脑组织IGF-1的含量,加强内源性保护机制。
Objective： To observe the effect of XinNaoTongLuoYe on the content of interleukin-8 and IGF-1 in brain of focal cerebral ischemia rats.Methods： To make the model of focal cerebral ischemia by inserting nylon thread,compared with Bu Chang Nao Xin Tong,the effect on infarct volume and the content of interleukin -8 and IGF-1in brain of focal cerebral ischemia rats were observed in 6h、12h、24h and 48h after cerebral ischemia.Results： 6h after cerebral ischemia,the content of interleukin-8 in brain increased,and it reached its chemia top in 48h（P 0.01）;Compared with model group,the content of IL-8 in brain of each treatment group was decreased except the control group,low-dose group in 6h、12h after cerebralischemia.（P 0.01orP 0.05）.in 6h after cerebral ischemia,the content of IGF-1 in brain increased and it reached top in 48h（P 0.01）;Compared with model group,the content of IGF-1 in brain of treatment group was increased （P 0.01）.Conclusion： XinNaoTongLuoYe can reduce content of IL-8 in cerebral tissue during cerebral ischemia and alleviate the level of inflammation.XinNaoTongLuoYe can increase content of IGF-1 in brain tissue which may be the endogenous protective mechanism during the ischemia situation.
出处
《中医药信息》
2010年第6期49-52,共4页
Information on Traditional Chinese Medicine
基金
黑龙江省自然科学基金项目(D2007-27)
关键词
心脑通络液
脑缺血
IL-8
IGF-1
XinNaoTongLuoYe
Cerebral ischemia
Interleukin-8
Insulin-like growth factor-1
