高血压病患者血清Ⅲ型、Ⅳ型前胶原、透明质酸浓度变化及苯那普利干预

The Serum Concentrations of ProcollagenⅢ,ProcollagenⅣ,Hyaluronic acid in Hypertensives and its Change after Benazepril Treatment

目的了解高血压病患者血清Ⅲ型前胶原（ＰⅢＰ）、Ⅳ型前胶原（ＰⅣＰ）、透明质酸（ＨＡ）的变化以及苯那普利对其影响。方法应用放射免疫技术测定４７例高血压患者和２１例健康体检者血清ＰⅢＰ、ＰⅣＰ、ＨＡ的浓度，并给高血压患者以苯那普利治疗十二周后复测上述指标。结果高血压组ＰⅢＰ、ＰⅣＰ、ＨＡ分别为１２６．８±１７．４μｇ／Ｌ，６４．１±１０．１７μｇ／Ｌ、７９．２３±９．７８μｇ／Ｌ明显高于对照组的８４．２±１１．９μｇ／Ｌ，５１．７２±９．２４μｇ／Ｌ、４１．３３±６．２５μｇ／Ｌ（Ｐ＜０．０１）；苯那普利治疗十二周后，高血压组上述指标分别为８９．４±１０．０９μｇ／Ｌ、５９．８±７．１μｇ／Ｌ、６５．４±８．１６μｇ／Ｌ，与治疗前相比Ｐ＜０．０１或Ｐ＜０．０５，差异显著，有统计学意义。结论血清ＰⅢＰ、ＰⅣＰ、ＨＡ水平与血压升高密切相关并致心肌纤维化。血管紧张素转换酶抑制剂－苯那普利能在有效控制血压的同时明显降低血清ＰⅢＰ、ＰⅣＰ。

Objective\ To explore the role of the serum concentrations of pro collagenⅢ(PⅢP), pro collagenⅣ(PⅣP), hyaluronic acid (HA) in hypertensives and its change after benazepril treatment.\ Methods\ Serum contents of PⅢP, PⅣP, HA were measured by radiommunoassay (RIA) in 47 patients with essential hypertension (EH) and 21 healthy individuals as control. EH patients were treated with benazepril for 12 weeks.\ Results\ Serum contents of PⅢP, PⅣP, HA in EH were 126.8±17.4 μg/L, 64.1±10.17 μg/L, 79,23±9.78 μg/L respectively. There are significantly higher than that in normal individuals(84.2±11.9 μg/L, 51.72±9.24 μg/L, 41.33±6.25 μg/L respectively). After 12 weeks of benazepril treatment, the levels of PⅢP, PⅣP, HA in EH decreased evidently with the reduction of blood pressure; however,they are still higher than that in healthy.\ Conclusion\ It is suggested that serum contents of PⅢP, PⅣP,HA are closely related with the rise of blood pressure. They may play role in the development of myocardial interstitial fibrosis. Benazepril reduces the serum contents of PⅢP, PⅣP, HA when the blood pressure is effectively controlled.