盐酸苯那普利治疗高血压病68例

Benazepril Treatment of 68 Cases Essential Hypertension

目的评价苯那普利的疗效及其对血脂、血糖、血尿素氮及肌酐代谢的影响。方法６８例原发性高血压患者给予苯那普利（洛汀新，诺华公司），剂量１０ｍｇ～２０ｍｇ／ｄ，治疗４周，另外５０例服用尼群地平患者２０～３０ｍｇ，每天二次。治疗前后所有参与者都作２４小时动态血压监测和测定胆固醇、三酰甘油、及血糖和尿素氮、肌酐测定。结果动态血压监测显示洛汀新降压较尼群地平为优。并对三酰甘油、血糖有较好影响。结论洛汀新治疗安全、有效，并能改善糖和脂质代谢。

Aim\ To evaluate the effects of benazepril(lotensen,Novartis) on essential hypertension and compare with nitrdipine.\ Methods\ Sixty eight patients were treated with benazepril,10 mg～20 mg/d and another fifty patients were treated with nitrendipine for four weeks.ABPM were monitored,Blood lipid,blood glucose,urea nitrogen,and creatinine were examined before and after treatment.\ Results\ Acoording pressure depressing criteria,the benazepril group is best than nitrendipine group. The effects on TG and glucose is more prominent than the nitrendipine group.\ Conclusion\ Lotensin is effective and safe in treatment of hypertension,and it had good effect in TG and glucose metabolism also.