氨氯地平治疗老年高血压的临床研究

Effects of Amlodipine on Left Ventricular Hypertrophy and Exercise BP in Elderly Hypertension

目的观察氨氯地平对老年高血压的治疗效果。方法本研究采用２４小时动态血压、超声心动图和平板运动检查，评价了氨氯地平对老年高血压患者左室肥厚和运动血压的影响。３６例按ＷＨＯ标准确诊为老年高血压者，排除继发性病因，停用降压药２周后给予氨氯地平５ｍｇ～７．５ｍｇ／ｄ，治疗四月。治疗前后行２４小时动态血压、超声心动图和平板运动试验检查。结果氨氯地平治疗后２４小时收缩压、舒张压及白昼、夜间收缩压、舒张压均明显低于治疗前；左室重量、室间隔厚度及左室后壁厚度亦明显减少；治疗后运动高峰时收缩压、运动停止后３分钟收缩压亦明显降低。结论氨氯地平能有效地降低老年高血压患者２４小时收缩压、舒张压，逆转心室肥厚，并明显降低患者运动时收缩压。

Aim\ To investigate the effect of amlodipine on left ventricular hypertrophy and exercise BP in elderly hypertension.\ Methods\ Echocardiography and ABPM were taken before and after 4 months amlodipine treatment 5 mg～7.5 mg/d. The changes of left ventricular hypertrophy and exercise test in BP were examined.\ [WT5 HZ]Results\ 24 h SBP and DBP were significantly decreased. The left ventricular wall thickness,ventricular mass,and peak exercise systolic BP were decreased significantly.\ Conclusion\ Amlodipine is effective in the treatment of hypertension in elderly.