急性多发性神经根神经炎外周血T淋巴细胞亚群的研究

Study of T Lymphocyte Subsets in Acute Polyradiculoneuritis

用抗人T细胞单克隆抗体OKT_3、OKT_4,OKT_8检测急性多发性神经根神经炎(AP)患者T淋巴细胞细胞亚群。共检测AP患者23例,正常对照20例,并观察不同病情、病型患者的T细胞亚群的改变。结果表明AP患者OKT_a^+、KT_4^+细胞百分率与正常对照组相同,但OKT_8^+细胞百分率明显低于对照组(P<0.05),OKT_4^+/OKT_a^+细胞比率相应升高(P<O.05)。不同病情及病型患者间T细胞亚群无明显差异,但随病程延长OKT_a^+细胞和OKT_4^+/OKT_8^+细胞比率逐渐恢复正常。结果提示细胞免疫紊乱可能在AP发病中有重要作用。

Ficol-Hypaque separated peripheral bloo dmononuclear cells were analysed by indirect immunofluorescence assay with ortho monoclonal antibodies to T cells (OKT_3^+), helper cells (OKT_4^+) and suppressor cytotoxic cells (OKT_8^+). 20 normal subjects and 23 patients with acute polyradiculoneuritis (AP) wore studied, The percentages of OKT_3^+ and OKT_4^+ cells were similar in the 2 groups, but the percentages of OKT_8^+ cells was reduced to 18.96±4.24 compared with 22.28±3.15 in the the normal subjects (P<0.05). The ratio of OKT_4^+/OKT_8^+ cells was correspondingly increased to 2.38±0.55, compared with 1.97±0.20 in the normal subjects. These changes fell towards normal with the passage of time. The result suggests that AP might be an autoimmunity disease with cell immunity disorders.