消化性溃疡血清一氧化氮含量变化及临床意义

DIGESTIVE ULCER SERUM NITRIC OXIDE CONTENT VARIATIONS AND ITS SIGNIFICANCE

目的与方法：用比色法测定了消化性溃疡６０例患者血清一氧化氮水平；结果：ＨＰ阳性溃疡组血清一氧化氮含量明显高于正常对照组以及ＨＰ阴性溃疡组（ｐ＜０．０１）。ＨＰ阴性溃疡组血清ＮＯ含量低于正常对照组（ｐ＜０．０５）；结论：提示ＨＰ感染可使血清ＮＯ水平过度增高，至使机体免疫防疫功能过强，造成自身组织损伤。而ＨＰ阴性溃疡组，可能存在内源性ＮＯ合成不足，前列腺素产生受抑，进而促进溃疡发生。

Objective and method:By using colorimetry ,the serum nitric oxide content of patients suffering from digestive ulcer is determined.Result:The results reveal that the serum nitric oxide content of HP positive ulcer group is obviously higher than that of the normal compared group and HP negative ulcer group(p<0.01),Serum NO content of HP negative ulcer group is lower than the normal compared group(p<0.05).Conclusion:Its revealed that HP infection may cause over high serum NO level and over strong immunity and epiodemic prevention function and therefore lead to self tissue damage;while HP negative ulcer group may have such problems as lack of intermal NO synthetic and restain of prostaglandn producing,and therefore promofe ulcer growth various content brings new thinking for curing the disease.