胃肠道恶性淋巴瘤的亚型与预后

Subtype and prognosis of malignant lymphoma in gastrointestinal tract

探讨胃肠道恶性淋巴瘤亚型与预后的关系。方法选取我院手术治疗的原发性胃肠淋巴瘤５０例，经切片复查并单克隆抗体标记。结果Ｂ细胞性４５例，Ｔ细胞性５例。随访证实，Ｔ细胞性病程短，进展快，化疗反应差，多在１ａ内死亡，５年存活率为２０％，明显低于Ｂ细胞性（４８．６％，Ｐ＜０．０５）。结论组织学分类是胃肠淋巴瘤判定预后的独立指标之一。影响预后的因素包括反应细胞来源的亚型分类，确诊时的临床分期及有无手术治疗的机会等。

In order to study the relationship between subtype and prognosis of malignant lymphoma in gastrointestinaltract. Methods Fifty cases of primary gastrointestinal malignant lymphoma admitted into our hospital were reported. ResultsImmnumohistochemical marks showed that the 45 cases of the total (90%)were B cell type,and 5 cases belonged to T Cell.T-NHL had a short disease course,was aggravated fast,and responsed poorly to chemotherapy.Most of the patients who suf-fered from T-cell NHL died within 1 year.5-year survival rate was 20%,which was lower than that in B-NHL (48.6%;P<0.05). Conclusion Exact histoclassification is an independent index in judging prognosis of malignant lymphoma in gastrointestinaltract.