老年不同营养状态肺心病患者炎性因子的测定及其与心功能相关性分析

Determination of inflammatory factors and correlation analysis of cardiac function about different nutritional status of elderly patients with pulmonary heart disease

目的研究肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)对老年肺心病营养状态和心功能的影响。方法用放射免疫法测定40例稳定期肺心病患者(分营养不良组A组20例,非营养不良组B组20例)和20例正常人血清TNF-α和IL-6的浓度,用心脏超声测定左室射血分数(LVEF)。结果 TNF-α和IL-6的浓度在各组均有升高,A组较B组及对照组均有增高,差异有显著性;B组较对照组有增高,但差异无显著性。TNF-α和IL-6与营养指标呈显著负相关,与心功能呈显著负相关。结论肺心病患者的营养状态及心功能与血清TNF-α和IL-6水平有一定的关系,TNF-α和IL-6增高可导致肺心病患者营养状态恶化及心功能恶化。

Objective To investigate the tumor necrosis factor - α （TNF - α） and interleukin - 6 （ IL - 6） pulmo- nary heart disease in elderly nutritional status and cardiac function. Methods By radioimmunoassay were measured in 40 pa- tients with stable chronic pulmonary heart disease （ group A sub - group of 20 cases of malnutrition, non - malnourished group B 20 patients） and 20 normal human serum TNF -α and IL -6 concentrations, with the cardiac ultrasound Left ventricular ejection fraction （LVEF）. Results TNF - α and IL - 6 concentrations increased in all groups, A group than in the B group and control group were higher, the difference was significant. From the B group than in the control group increased, the difference was not statistically significant. TNF - α and IL - 6 and nutritional parameters was significantly negatively correla- ted with cardiac function was significantly negatively correlated. Conclusion Nutritional status in patients with pulmonary heart disease and cardiac function and serum TNF - α and IL - 6 levels have a certain relationship, TNF - α and IL - 6 increased in patients with pulmonary heart disease can lead to deterioration in nutritional status and heart function deteriorated.