摘要
目的 探讨凋亡相关基因Fas/APO1和Bcl2在肺癌发生发展中的作用。方法 采用免疫组织化学方法对65例肺癌组织和46例远离肺癌正常肺组织Fas/APO1和Bcl2蛋白的表达进行检测。结果 肺癌组织Fas/APO1蛋白阳性表达率(56.92%)明显低于正常肺组织的阳性表达率(82.61%)(P<0.01),而Bcl2蛋白阳性表达率(46.15%)明显高于正常肺组织的阳性表达率(6.52%)(P<0.01)。
Objective To investigate the role of Fas/APO 1 and Bcl 2 in oncogenesis and progression of lung cancer. Methods The expression of Fas/APO 1 and Bcl 2 protein were detected in 65 lung cancer tissues and 46 normal lung tissues by immunohistochemistry. Results The positive rate of Fas/APO 1 protein expression in lung cancer tissues was 56.92%, which was significantly lower than that in normal lung tissues(82.61%)(P<0.01). The positive rate of Bcl 2 protein expression was 46.15%. It was significantly higher than that in normal lung tissues(6.52%)(P<0.01).Conclusion Both Fas/APO 1 and Bcl 2 may play an role in the oncogenesis and progression of lung cancer.
