皮下注射氯胺酮外周镇痛的临床观察

Ketamine for peripheral analgesia in human in vitro

为观察氯胺酮在人体外周是否有镇痛作用，随机将２０例下肢短小手术患者分为两组：Ⅰ组为生理盐水组；Ⅱ组为氯胺酮组。用改进的止血带法进行疼痛刺激，分别在注射氯胺酮前、后第５ｍｉｎ两个时点以视觉模拟评分法（ＶＡＳ）进行疼痛测定。结果患者在注射氯胺酮后第５ｍｉｎ与注射前相比，有明显的镇痛作用，Ｐ＜０．０１。认为氯胺酮对人体的皮肤压痛有明显的镇痛作用。

To investigate whether or not Ketamine had peripheral analgesia in human in vitro, twenty patients who had undergone short-limb surgery were randomly divided into two groups: group I, the normal saline group; group II, the Ketamine group. The improved hemostasis with tourniquet was used to induce pain. Visual analog score (VAS) was used to assess pain at the points of before and after 5 mintutes subcutaneous injection of Ketamine. Results showed that patients had notable analgesia after the injection, compared to before the injection and it is statistical significant, P <0 01 It is concluded that low-dose ketamine can be given in clinical peripheral analgesia.