直肠癌病人血液流变学变化的研究

Study of hemorheology changes in patients with rectal cancer

目的研究直肠癌病人血液流变学的改变特点。方法选择直肠癌病人67例为实验组,同期健康人员60例为对照组,测定相关血液流变学指标、甘油三酯和胆固醇。结果直肠癌病人的全血粘度、全血还原粘度、血浆粘度、血沉方程K值、红细胞刚性指数、红细胞聚集指数、纤维蛋白原高于对照组,不同Dukes分期的直肠癌病人其血液流变学改变不一致,全血还原粘度、血浆粘度、血沉方程K值、红细胞刚性指数、红细胞聚集指数、纤维蛋白原在B、C、D三期均明显升高,而血沉、全血相对粘度仅在某一病理分期升高。结论直肠癌病人存在血液流变学的异常,判断直肠癌病人血液流变学的改变要选择合适的血液流变学指标,血液流变学对于直肠癌的诊断、术前分期有一定的意义。

[Objective] To investigate the changes of hemorheology in patients with rectal cancer.[Methods] 67 patients with rectal cancer and 60 healthy individuals as control group were invited to participate,hemorheological parameters,triglyceride and cholesterin were detected.[Results] Patients with rectal cancer showed hyperviscosity,which presented with the increase of blood viscosity,blood reduced viscosity,plasma viscosity,K value of erythrocyte sedimentation rate equation,erythrocyte rigidity index,erythrocyte aggregation index and fibrinogen.Patients in different stage by Dukes assay showed different changes in hemorheology.The level of blood reduced viscosity,plasma viscosity,K value of erythrocyte sedimentation rate equation,erythrocyte rigidity index,erythrocyte aggregation index and fibrinogen were higher in B,C and D stages,while the level of erythrocyte sedimentation rate and blood relative viscosity were higher only at certain pathological stage.[Conclusions] Abnormality in hemorheology occurs in rectal cancer patients,proper parameters of hemorheology should be selected to reflect the abnormality in hemorrheology,which show much significance in diagnosis and judgement of pathological stage before operation in rectal cancer patients.