原发性小肠癌的预后因素分析

Prognostic Factors of Primary Small Intestinal Carcinoma

目的探讨原发性小肠癌的诊断、治疗方法及其主要预后因素。方法回顾性分析我院1978年-2009年间收治并经病理证实的33例原发性小肠癌的临床资料,所有数据采用Kaplan-Meier法进行生存率分析,利用log-rank检验进行统计学差异性比较,应用Cox比例风险模型进行预后多因素分析。结果除患者的构成和肿瘤的生长部位对生存率无明显影响外,肿瘤分期、病理类型和分化程度以及治疗方法对生存率都有重要影响,P值均<0.01,差异具有显著性。结论虽然小肠癌患者的生存率总体较低,但早期诊断并行根治性手术可望改善预后,提高无病生存率,化疗对延长生存率作用不大,其价值有待商榷。

[Objective] To investigate the diagnosis and management of primary small intestinal carcinoma and identify the most important prognostic factors of the disease.[Methods] The clinical data of 33 patients suffered primary small intestinal carcinoma（1979~2009）were analyzed retrospectively.Survival analysis was made by Kaplan-Meier curve;unvaried differences in survival were compared using the Log-rank test;and multivariate analyses were performed using a Cox regression model.[Results] The sex,age and position of tumor were not very important prognostics of primary small intestinal carcinoma.However,the influence of tumor stage,pathology type and management to small intestinal carcinoma was significant,P0.01.[Conclusions] Although the overall survival is fairly low,early diagnosis and radical surgery were hoped to improve the prognosis and enhance the disease free survival.The value of chemo-therapy to primary small intestinal carcinoma was no found.