肝动脉化疗栓塞+^(32)P午治疗原发性肝癌患者后sIL-2R、T淋巴细胞亚群改变

Alteration of soluble interleukin 2 receptor and T lymphocyte subsets in Patients with liver cancer after TAE +( 32)~P

观测原发性肝癌患者经肝动脉化疗栓塞（ＴＡＥ）＋３２Ｐ内照射治疗后免疫功能状态改变。方法检测２３例ＴＡＮ＋３２Ｐ治疗后原发性肝癌患者和２０例健康献血员血液可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）、辅助Ｔ淋巴细胞、抑制Ｔ淋巴细胞。结果原发性肝癌患者Ｔｈ细胞比健康对照组显著下降（Ｐ＜０．０５），ｓＩＬ－２Ｒ、Ｔｓ细胞比健康对照组明显增高（Ｐ＜０．０５）；ＴＡＥ＋３２Ｐ治疗后原发性肝癌患者Ｔｈ细胞明显增高（Ｐ＜０．０５），ｓＩＬ－２Ｒ、Ｔｓ细胞非常显著降低（Ｐ＜０．０１）。结论测定ＴＡＥ＋３２Ｐ治疗原发性肝癌患者血液中ｓＩＬ－２Ｒ、Ｔｈ、Ｔｓ细胞对判断患者免疫功能状态、疗效、预后有一定的价值。

Aim ln oafer to know immune state in patients with liver cancer after transcatheter hepatic artery embolization (TAE) + 32P. Methods We determined serum soluble interleukin 2 receptor and T lylnphocyte subsets in 23 patients with liver cancer and 20 healthy subjects. Results The results showed that in patients with liver cancer HelP T cellsrmlower (P < 0. 05 ); sIL - 2R. Suppress T cells were significantly higher (P < 0. 05 ) than those in control group. The cells in patients with liver cancer became higher and sIL - 2R. Ts cells became lower remarkably(P < 0. 05. P < 0. 01 ). ConclusionMeasurement of Th.Ts cells and sIL - 2R after TAE + 32P has certain value for evaluating immune state .treating effection andprognosis in patients with liver cancer.