摘要
目的:探讨不同中医证型维吾尔族溃疡性结肠炎患者血清趋化因子白介素-8(IL-8)及单核细胞趋化蛋白-1(MCP-1)水平的变化与结肠组织过氧化物酶(MPO)的相关性,以及其临床意义,为临床辨证提供客观化指标。方法:采用ELISA法检测70例不同中医证型维吾尔族溃疡性结肠炎患者血清白介素-8(IL-8)及单核细胞趋化蛋白-1(MCP-1)水平;结肠组织MPO含量采用生化方法检测,同时观察IL-8及MCP-1水平与结肠组织MPO含量的关系。结果:不同中医证型维吾尔族溃疡性结肠炎患者IL-8及MCP-1水平,结肠组织MPO含量均高于正常对照(P<0.05);血清IL-8、MCP-1水平与患者MPO含量呈正相关(r=0.7535、0.8266、0.7638;P<0.05)。结论:维吾尔族UC患者中趋化因子IL-8及MCP-1可能参与了溃疡性结肠炎炎症损伤过程,血清IL-8及MCP-1水平增高可以做为湿热内蕴证和气滞血瘀证的客观化指标。
Objective： To explore the different syndromes in patients with ulcerative colitis Uygur chemokine interleukin -8 （IL-8） and monocyte chemoattractant protein -1 （MCP-1） levels in patients with colon myeloperoxidase （MPO） of relevance, and its clinical signifi- cance, as the clinical syndrome to provide objective metrics. Methods： The ELISA method detected 70 cases of different syndromes in patients with ulcerative colitis Uighur Interleukin -8 （IL-8） and monocyte chemoattractant protein -1 （MCP-1） levels; colon MPO levels detected by biochemical methods, while observing the IL-8 and MCP-1 levels and the relationship between colon tissue MPO content. Resuits： （1） Uighur different syndromes in patients with ulcerative colitis in IL-8 and MCP-1 levels, colon tissue MPO levels were higher than normal controls （P〈0.05）; serum IL-8, MCP-1 levels in patients MPO levels were positively correlated （r = 0.7535, 0.8266, 0.7638; P〈0.05）.Conclusion： UC patients chemokine IL-8 and MCP-1 may be involved in the inflammation of ulcerative colitis injury, serum IL-8 and MCP-1 levels can increase as evidence of dampness and Qi stagnation objective evidence of indicators.
出处
《内蒙古中医药》
2010年第21期61-62,共2页
Inner Mongolia Journal of Traditional Chinese Medicine
