原发性高血压患者血清胆红素、尿酸及超敏C反应蛋白变化的临床意义

Clinical significance of serum bilirubin,uric acid and high sensitivity C-reactive protein in patients with essential hypertension

目的探讨原发性高血压(EH)患者血清胆红素、尿酸(UA)及超敏C反应蛋白(hs-CRP)变化的临床意义。方法选择EH患者101例(EH组)、阵发性室上性心动过速患者103例(对照组),检测其血清胆红素、UA及hs-CRP。结果与对照组比较,EH组血清总胆红素、直接胆红素和间接胆红素明显降低,且随高血压分级升高而逐渐降低(P<0.05);血清UA、hs-CRP明显升高,且随高血压分级升高而逐渐升高(P<0.05)。结论血清胆红素、UA和hs-CRP是反映EH患者代谢异常的重要指标,可用于评估其病情的严重程度。

Objective To investigate the clinical significance of serum bilirubin, uric acid and high sensitivity C-reactive protein（hs-CRP） in patients with essential hypertension（EH）. Methods The levels of serum bilirubin, uric acid and hs-CRP were measured respectively in 101 patients with EH（ EH group） and 103 patients with paroxysmal supraventfieular tachyeardia as controls（ control group）. Results The levels of serum total bilirubin, direct bilirubin and indirect bilirubin in EH group were significantly lower than those in control group（ P 〈 0.05 ）, moreover, the levels of serum bilirubin decreased while the classification of EH rised. However, the levels of uric acid and hs-CRP were significantly higher than those in control group（P 〈0.05）, and the levels of serum uric acid and hs-CRP increased while the classification of EH rise＆ Conclusions Serum bilirubin,uric acid and hs-CRP may play an important role in metabolic disturbance in patients with EH and can be used to evaluate the severity of the illness in such patients.