摘要
以对氯苯甲醛、烯丙基氯为原料,经过格氏反应、二氧化锰氧化反应和Simmons-smith反应生成中间体1-(4-氯苯基)-2-环丙基-1-乙酮(1),总收率为56.4%。产品和所有中间体经1H NMR确证。此路线采用的原料价廉易得,无特殊反应及操作要求,有较好的工业化应用前景。
2-Cyclopropyl-1-(4'-chloro)acetophenone(1) was synthesized from 4-chlorobenzaldehyde and allyl chloride in overall yield of 56.4% via Grignard reaction,oxidation and Simmons-Smith reaction.The target product and all intermediates were confirmed with 1H NMR spectra.
出处
《精细化工中间体》
CAS
2010年第5期27-28,共2页
Fine Chemical Intermediates