新生儿接种不同批号冻干卡介苗的临床反应和免疫效果观察

Comparison of the Immunological Efficacy in Newborns of Different nits of Lyophilized BCG Vaccine After Intradermal Injection

为考核冻干卡介苗（BCG）的质量，对上海市普陀区、江苏省南京市新生儿接种不同批号冻干BCG的临床反应及免疫效果进行了观察。结果显示：接种不同批号BCG后均无腋下淋巴结肿大等副反应；两地各组新生儿阳转率为98％～100％，不同地区新生儿接种同一批BCG，因个体差异等因素导致结核菌素纯蛋白衍化物（T-PPD）硬结平均直径的差异有显著的统计学意义（t=5537～10.951。P＜001）；而不同批号BCG之间由于活菌数不同，与对照BCG的PPD试验的硬结平均直径比较，差异也各不相同（t=0．142～4．054，P＜0.05或＞0．05）;卡痕阳性率高于94.59％，PPD试验与卡痕反应判定的符合率为94.81％。

This paper reported the immunological efficacy and side reactions of different lots oflyophilized BCG vaccine in newborn in Potuo district of Shanghai and Naming mwhcipalityof Jiangsu Province. The results showed that all lots of BCG vaccine gave nice inunuulolgical efficacy and no side reactions. The same lot of BCG vaccine showed different efficacy in the different cities, it was related with their dose of injection, the average diameter of PPD scleromawas significantly different between two cities (t=5.537 -- 10.951, p <0.01). Because of the different viable bacteria counts in various lots, the inununological efficacy was significantly different. The result of scar reaction matched with that of the PPD testing at the level of abode94.81 %.