生精细胞凋亡与男性不育症

Apoptosis of germ cells and male infertility

近年来,随着对细胞凋亡认识的不断加深,医疗及科研工作者越来越关注细胞凋亡与疾病之间的联系,并为此展开了一系列的试验。现已明确凋亡是人体正常生长发育所必需的,但其失衡也与许多疾病的发生关系密切。生精细胞凋亡过度可能是导致男性不育的重要原因之一。而caspases是细胞凋亡末期的共同通道,对细胞凋亡起着关键性的作用。因此,对caspases家族的活性调控研究可能为治疗男性不育提供新的诊断标准及治疗途径。

In recent years,with the increasing knowledge about apoptosis,scientists and medical practitio-ners have paid more attention on the relationship between apoptosis and diseases,and they also have carried on a lot of experiments.Now,it is clear that apoptosis is necessary for human beings’normal growth and development,while it may lead to diseases if it cannot keep balance.One of the most important reasons for male infertility is too much apoptosis in germ cells.As the common path of apoptosis,caspases play a key role in apoptosis.So the regula-tion of caspases may provide a new diagnosis standard and treatment therapy for male infertility.