海口地区女性解脲脲原体感染及耐药情况分析

Analysis of infection and drug-resistence of ureaplasma urealyticum of the women in haikou

目的研究海口地区泌尿生殖道解脲脲原体感染情况和药敏变化,指导临床合理用药。方法用珠海丽珠生物技术研究所生产的支原体药敏试剂盒检测902例宫颈分泌物,分析其感染情况和常用抗生素的药敏状况。结果 902例受检患者解脲脲原体培养阳性398例;各个年龄组的女性解脲脲原体感染阳性率差异无统计学意义(P>0.05)。对各种抗生素的耐药率为:强力霉素15.33%、美满霉素7.04%、交沙霉素1.51%、克拉霉素13.07%、罗红霉素15.33%、阿奇霉素14.82%、氧氟沙星23.37%、左旋氧氟沙星10.80%、司帕沙星13.57%。同一种药物在不同年龄段患者的敏感率是不同的,不同药物的最高敏感率分布的年龄段差不多。结论解脲脲原体对四环素类的美满霉素和大环内脂类的交沙霉素的敏感性较高,均超过95%,可作为治疗支原体感染的首选抗生素和经验用药。

Objective To study the infection of the genitourinary tract and drug-resistence of Ureaplasma ure？ alyticum in Haikou to guide reasonable clinical medication.Methods 398 samples of the patients diagnosed as Urea？ plasma urealyticum were analyzed the drug-resistence of common antibiotics during December 2009 and June 2010.Results 398 cases diagnosed as Ureaplasma urealyticum among 902 patientssamples are positive;the positive rate of different age of women are not statistically significant.The susceptibility of different kinds of antibiotics follows： deoxycyline 15.33%,minoccyline 7.04%,josamycin 1.51%,clarithromycin 13.07%,roxithromycin1 5.33%,azithro-mycin 14.82%,ofloxacin 23.37%,levofloxacin 10.80%,sparfloxacin 13.57%.Conclusion Test of drug-resistence of ureaplasma urealyticum can guide reasonable clinical medication.