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反向遗传学技术在狂犬病病毒研究中的应用 被引量：3

Use of reverse genetics in the study of the rabies virus
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摘要 狂犬病是一种重要的人兽共患病,病死率几乎达100%,是全球性的重要公共卫生问题。近年来,尽管对狂犬病的防控取得了很大进展,但狂犬病病毒致病机理的研究仍有待深化。反向遗传学是一门新兴学科,近年来已广泛应用于狂犬病病毒研究中的各个领域。本文着重介绍反向遗传学技术在狂犬病病毒基因结构、致病机理、新型载体和疫苗研发中的应用,并对其未来发展方向进行了展望。 Rabies is a major zoonotic disease that remains an important public health problem worldwide,with a mortality rate of about 100%.Although significant advances have been made in rabies prevention and control,the pathogenic mechanisms by which the rabies virus acts have yet to be fully elucidated.As a new branch of science,reverse genetics has been widely used to study the rabies virus.This review describes advances in the use of reverse genetics to study the genetic structure,pathogenic mechanisms,and new viral vectors of the rabies virus and to develop vaccines;this review also describes prospects for the future study of the virus.
作者 齐瑛琳 杨松涛 金宏丽 赵丽丽 冯娜 夏咸柱
机构地区 吉林大学农学部畜牧兽医学院 中国人民解放军军事医学科学院军事兽医研究所
出处 《中国病原生物学杂志》 CSCD 2010年第11期865-868,共4页 Journal of Pathogen Biology
基金 "十一五"国家科技支撑计划项目(No.2010BAD04B02) 农业公益性行业项目(No.200803014)
关键词 狂犬病病毒 反向遗传学技术 综述 Rabies virus reverse genetic technique review
分类号 R373.9 [医药卫生—病原生物学]
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参考文献43

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二级参考文献31

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共引文献29

同被引文献36

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中国病原生物学杂志
2010年 第11期

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