认知功能训练联合尼莫地平对急性脑梗死认知功能障碍患者的影响

Research of nimodipine combined with cognitive training on cognitive impairment in acute cerebral infarction patients

目的探讨尼莫地平联合认知功能训练对急性脑脑梗死认知功能障碍患者的影响。方法选择我院2007-11～2009-11急性脑梗死认知功能障碍患者81例,将以上患者随机分为2组,观察组和对照组。对照组患者给予常规神经内科治疗,同时给予物理治疗、作业治疗等。在对照组治疗基础上,观察组给予认知功能训练和尼莫地平治疗。2组患者均治疗3个月。患者治疗前和治疗3个月后,采用神经行为认知状态测试(NCSE)量表、画钟试验(CDT)、欧洲神经功能缺损评分(ESS)、Fugl-Meyer(FMA)量表、Barthel Index对患者进行评分。结果观察组治疗3个月后NCSE总评分和画钟试验(CDT)评分分别与对照组治疗3个月后比较,差异有统计学意义(P<0.05);观察组治疗3个月后ESS评分、FAM评分和日常生活活动能力评分分别与对照组治疗3个月后比较,差异有统计学意义(P<0.05)。结论尼莫地平联合认知功能训练有助于改善急性脑脑梗死后认知功能障碍,有利于提高患者的肢体运动功能和日常生活活动能力,临床效果显著,值得借鉴。

Objective To explore the inference of nimodipine combined with cognitive training on cognitive impairment after acute cerebral infarction. Methods Eighty-one patients with cognitive impairment after acute cerebral infarction were selected from November 2007 to November 2009 ,and were randomly divided into observation group and control group. Control group was given routine treatment of neurology department, physical therapy and occupational therapy. On the basis of the treatment of control group,nimodipine combined with cognitive training was used for observation group. The course was 3 months in the two groups. The Neurobehavioral Cognitive Status Examination（NCSE）, Clock Drawing Test（CDT）, European Stroke Scale （ESS）, Fugl-Meyer Assessment （FMA）, Barthel Index （BI）were used before treatment and after treatment for 3 months. Results Compared with control group, The scores of NCSE and CDT after treatment for 3 months in observation group had statistical difference（P〈0. 05） ;Compared with control group, the scores of ESS, FAM and BI in observation group after treatment for 3 months had statistical difference（P〈0.05）. Conclusion Nimodipine combined with cognitive training can improve the cognitive impairment after acute cerebral infarction, and improve the motor function of limbs and the activities of daily living. The clinical efficacy is significant,and it is worthy of learning by doctors.