进展性脑梗死的危险因素及临床研究

Clinical study on the risk factors of progressive cerebral infarction

目的探讨进展性脑梗死的危险因素及临床特点。方法对进展性脑梗死组(68例)和非进展脑梗死组(92例)进行统计分析比较,一般情况、既往史、血常规、凝血全项、血脂血糖、颈动脉彩超、同型半胱氨酸(Hcy)、纤维蛋白原(Fb)、C-反应蛋白的差异性。结果进展组的高血压、糖尿病发生率均高于非进展组(P<0.01),C-反应蛋白、白细胞计数、血浆Hcy和Fb均有统计学意义(P<0.01)。进展组溃疡斑10例,软斑34例,明显高于非进展组。结论高血压、糖尿病、感染、高同型半胱氨酸血症(Hhcy)、动脉硬化斑块可能是进展性脑梗死的危险因素。

Objective To investigate the risk factors and the clinical characteristics of progressive cerebral infarction. Methods The patients with cerebral infarction were randomized into two groups： progressive cerebral infarction group （n=68） and non-progressive cerebral infarction group（n= 92）. The patients＇ material of past history, blood test, blood clotting set, blood lipid and blood sugar, carotid artery ultrasound （CAU）, Hcy, Fb, CRP in the two groups were compared. Results There was a higher incidence rate of hypertension and diabetes in the progressive cerebral infarction group （P〈0.01）. There were significant differences in the levels of CRP, white blood cell count, Hcy, Fb between the two groups （P〈0.01）. As the carotid artery arteriosclerotic plaques, there were 10 cases with ulcer plaque and 34 cases with soft plaque in the progressive cerebral infarction group, which was significantly higher than that of no,progressive cerebral infarction group. Conclusion Hypertension, diabetes, infection, Hhcy and carotid artery arteriosclerotic plaques may be the risk factors of progressive cerebral infarction.