冷热敷时间对硫酸镁治疗兔耳缘静脉炎影响的实验研究

Experimental study on influence of time of magnesium sulfate cold and hot compress to treat ear phlebitis of rabbit

[目的]探讨硫酸镁冷热敷交替治疗静脉炎的最佳时机。[方法]静脉注射20%甘露醇建立兔耳缘静脉硬结型静脉炎模型,将24只建模成功的新西兰大白兔随机分为4组,均予50%硫酸镁湿敷。对照组为常温湿敷,实验1组、实验2组、实验3组分别冷敷12 h2、4 h4、8 h后换为热敷治疗。湿敷72 h后,大体观察及病理切片观察血管壁损伤程度、血管周围出血程度、血管淤血程度、炎细胞浸润程度、纤维组织增生程度、血栓形成程度、水肿程度。[结果]实验1组、实验2组较对照组、实验3组静脉总体损伤程度显著降低;血管壁损伤程度、血管周围出血程度、血管淤血程度、纤维组织增生程度、水肿程度各组比较差异均有统计学意义。[结论]硫酸镁治疗静脉炎冷热敷交替的最佳时机为12 h^24 h。

Objective：To probe into the optimal time of magnesium sulfate cold and hot alternative compress to treat phlebitis.Methods：To prepare sclerosis ear phlebitis rabbit model by intravenous infusion of 20% mannitol,a total of 24 New Zealand white rabbits were divided into 4 groups randomly and all were given 50% magnesium sulfate wet compress.Rabbits of control group were given wet dressing under room temperature.Rabbits of test group 1,test group 2,and test group 3 were given magnesium sulfate hot compress at 12 h,24 h,48 h after cold compress treatment respectively.After 72 h wet compress,the degree of vascular wall damage,perivascular hemorrhage,the degree of vascular congestion,fibrous tissue hyperplasia,and edema of all rabbits were observed on general morphous and pathological slice.Results：In terms of general damage degree,rabbits of test group 1 and test group 2 were less than that of control group and test group 3 rabbits.There were significant statistical differences among them in terms of degrees of vascular wall injury,perivascular hemorrhage,vascular congestion,fibrous tissue hyperplasia,and edema.Conclusion：The optimal time of magnesium sulfate hot and cold alternating compress to treat phlebitis is 12 hours to 24 hours.