期刊文献+

EPO在骨肉瘤中的表达及统计分析

下载PDF
导出
摘要 目的:探讨EPO在骨肉瘤组织中的表达及意义。方法:收集武汉市四大三级甲医院的骨肉瘤20例及良性骨软骨瘤5例,将实验分为骨肉瘤组(n=20)和良性骨软骨瘤组(n=5),采用免疫组织化学方法检测各组组织中EPO的表达水平,采用HPIAS-1000图文报告管理系统对EPO的表达进行定量分析,并用SPSS13.5软件对各组免疫组织化学反应阳性颗粒平均光密度、阳性面积率做单因素方差分析和SNK(q)检验。结果:EPO在骨肉瘤组织中呈高表达,EPO在良性骨软骨瘤组织中呈低表达,EPO在骨肉瘤组织中的表达与良性骨软骨瘤组织的表达比较差异有显著性(P<0.05)。结论:EPO在肿瘤的发生发展等过程中起了重要作用。
出处 《数理医药学杂志》 2010年第6期675-677,共3页 Journal of Mathematical Medicine
  • 相关文献

参考文献15

  • 1Meyers P,Schwartz C,Krailo M,et al.Osteosarcoma:A randomized,prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin,doxorubicin,and high-dose methotrexate.J Clin Oncol,2005,23(9):2004-2011.
  • 2Mialou V,Philip T,Kalifa C,et al.Metastatic osteosarcoma at diagnosis:prognostic factors and longterm outcome-the French Pediatric Experience.Cancer,2005,104(5):1100-1109.
  • 3Perbal B,Zuntini M,Zambelli D,et al.Prognostic value of CCN3 in osteosarcoma.Clin Cancer Res,2008,14(3):701-09.
  • 4Westenfelder C,Baranowski RL.Erythropoietin stimulates proliferation of human renal carcinoma ce1ls.Kidney Int,2000,58:647-657.
  • 5McBr oom JW,Acs G,Rose GS,et al.Erythropoeitin receptor function and expression in epithelial ovarian carcinoma.Gynecol Oncol,2005,7:25-31.
  • 6Acs G,Zhang PJ,Rebbeck TR,et al.Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma.Cancer,2002,95:969-981.
  • 7Kubo T,Piperdi S,Rosenblum J,et al.Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma.Cancer,2008,112(10):2119-2129.
  • 8Hashimoto Y,Skacelm,Adams J C.Roles of fascin in human carcinomamotility and signaling:prospects fora novelbiomarker? IntJBiochem CellBio,2005,37:1787-1804.
  • 9Dillard DG,Venkatraman G,Cohen C,et al.I mmuno-localiza tion of erythropoietin and erythropoietin receptor in vestibular-schwannoma.Acta Otolaryngo1,2001,121:149-152.
  • 10KouryMJ,BondurantMC.Erythr opoietin retards DNA breakdown and prevents protrammeddeath in erythroid progenitor cell.Science,1990,248:378-387.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部