刺激疑核对甲状腺功能的影响

Effect of Stimulating Nucleus Ambiguus on the Function of Thyroid in Rabbits

实验用3-4月龄健康青紫蓝家兔15只,麻醉后于AP20-219L1-1.8处插入同心圆电极(H20-21),用电子刺激器刺激。在刺激前及刺激后每隔一定时间采血检测血浆中T3、T4、TSH含量。实验完毕,用电损毁法做极尖定位,并做组织学检查,电极尖端位于疑核的作为实验组(10例),余为对照组(5例)。对其中6例(实验组3例,对照组3例)采取两侧甲状腺做超微结构观察。结果:刺激疑核后血浆中T3、T4含量下降,TSH含量无变化,而对照组T3、T4、TSH变化均不明显;实验组甲状腺显示滤泡上皮细胞功能不活跃的结构相,对照组显示功能较旺盛的结构相。由此认为,疑核与甲状腺之间存在机能联系,刺激疑核可引起甲状腺功能抑制,并且这种联系可能是由起源于疑核,支配甲状腺的副交感神经所介导的。

Studies were undertaken to determine the effect of stimulating nucleus ambiguus (NA) on the function of thyroid in rabbits. The results were as follows: In experimental group, the levels of T3, T4 decreased significantly, but TSH level did not change.There were no obvious changes of the T3, T4, TSH in control group. The thyroid ultrastructure of the experimental group presented an inactive structure feature,but that of the control was active. The results suggested that there is not only structural connection but also functional connection between NA and thyroid. The function of thyroid is depressed by stimulating NA. This depression is mediated by parasympathetic nerve which originates from NA and innervates the thyroid.