女性生长发育及生殖内分泌系统对环境有机污染物暴露的敏感性

Sensitivity of Exposure to Environmental Organic Contaminants for Developmental and Reproductive Endocrine of Women

随着现代工业的发展,环境有机污染物对人类生殖内分泌系统发育的毒性作用越来越受到重视。环境有机污染物可蓄积在人体内,并可干扰内分泌,影响着人类健康。来自塑料、化妆品、食品包装等日常物品中的主要常见有机污染物包括邻苯二甲酸酯类(phthalate esters,PAEs),双酚A(bisphenol A,BPA)类,烷基酚(alkyl-phenol)类,多氯联苯类(polychlorinated biphenyls,PCBs),二噁英(dioxin)等。本文主要关注常见的具有干扰女性生长发育过程,影响女性内分泌,导致胚胎发育异常,甚至导致肿瘤发生的几种环境有机污染物。女性担负着繁育下一代的重任,其健康对人口素质有着重大影响。故研究环境有机污染物对女性的危害,具重要意义。本文就女性生长发育及生殖内分泌系统对环境有机污染物暴露的敏感性,综述如下。

With the development of modern industry, more and more people pay close attention to the developmental and reproductive toxicity of environmental organic contaminants. These stuffs, accumulating in the human body, have the disruption of the endocrine. Main common organic contaminants are phthalate esters （PAEs）, bisphenol A （BPA）, alkyl-phenols, polyehlorinated biphenyls （ PCBs）, dioxin, etc. There were many researches about the toxicity ol the male reproductive system, but few for the female. In the modern life, women play an increasing important role, and undertake an important responsibility of breeding the next generation. In this paper, we focus on the sensitivity of exposure to environmental organic contaminants for the development and reproductive endocrine of women.