摘要
健康水貂6只,3只作对照,另3只口服-20℃保存9个月的水貂细小病毒性肠炎粪毒。实验貂临床症状典型,小肠粘膜出现“气球样”上皮细胞,肠腺和绒毛上皮细胞广泛变性、坏死、脱落,胞浆内可见嗜酸性小体;胞核可见两种类型Cowdry A型包涵体;在肠系膜淋巴结、骨髓、脾和肾上腺也观察到了核内包涵体。在小肠绒毛上皮细胞膜上和肠腺腺腔中发现大量G-小杆菌。同时,用扫描电镜观察了各肠段粘膜表面的变化;用透射电镜研究了空肠前段粘膜上皮细胞中水貂细小病毒(MPV)的形态发生及其所引起的超微病变,发现核仁及其相随染色质参与了核内包涵体的形成。
Seven healthy minks were used, three as control, the others were inoculated orally with parvovirus from feces. The inoculated ones showed typical symptom of mink parvovirus enteritis. The pathological changes were observed under optical microscope, and the ultrastructural changes of the mucous membrane of intestine were observed with scanning and transmission electron microscopy.
关键词
水貂
肠炎
细小病毒性
病理形态学
mink
parvovirus
pathomorphology, inclusion bodies
eosinophilic body
