T2DM颈动脉粥样硬化hs—CRP水平及阿司匹林对其影响

目的探讨超敏C-反应蛋白（hs—CRP）在2型糖尿病（T2DM）颈动脉粥样硬化中的水平及阿司匹林对其影响。方法正常对照组（A组）30例，T2DM无颈动脉粥样硬化组（B组）35例，T2DM颈动脉粥样硬化组（C组）30例，分别检测hs—CRP、体重指数、空腹血糖、糖化血红蛋白，B组和C组患者服阿刮匹林，4周后复查hs—CRP。结果B组和C组hs—CRP浓度显著高于A组（P〈0．01），C组显著高于B组（P〈0．05）。经阿司匹林治疗后，hs—CRP浓度变化B组差异无统计学意义，而C组差异有统汁学意义（P〈0．05）。结论hs—CRP与T2DM及其颈动脉粥样硬化密切相关，长期小剂量的阿司匹林可降低hs—CRP水平，从而可延缓T2DM颈动脉粥样硬化的发展。

Objective To study serum high sensitivity C - reactive protein （ hs - CRP） level in type 2 diabetes mellitus （T2DM） with carotid atherosclerosis and effects of aspilin on it. Methods We measured hs- CRP, body mass index （BMI）, fasting plasma glucose （FPG）, glycosylated hemoglobin Alc （HbA1c） and recorde hypertension, hyperlipemia, smoking in normal contral （ group A） , T2 DM without carotid atherosclerosis （ group B ） and T2 DM with carotid atherosclerosis （ group C ）. Serum hs - CRP level was examined again after 4 weeks use of aspilin of 100 mg in T2DM. Results Serum hs - CRP was significant higher in group B and group C than group A （P 〈 0. 01 ） , group C was also significant higher than group B （P 〈 0. 05 ）. After use of aspilin hs - CRP in group B could not be significantly reduced, but in group C could be significantly reduced （ P 〈 0. 05 ）. Conclusions Hs - CRP closely eorrelats with T2DM and T2DM with carotid atherosclerosis. Using small dosage of aspilin can reduce the serum hs - CRP level and may prevent the development of T2DM with carotid atherosclerosis.