降低低密度脂蛋白水平与急性冠脉综合征预后的关系

目的探讨应用他汀类药物降低低密度胆固醇（LDL—C）与急性冠脉综合征（ACS）患者严重心血管事件发生率的关系。方法115例PCI术后急性冠脉综合征患者，规则服用他汀类和其他药物，根据LDL—C水平分组：2．07～3．36mmol／L为正常组，〈2．07mmol／L为低水平组。然后再将低水平组分为两组：1．55～2．07mmoL／L为较低水平组，〈1．55mmol／L为极低水平组。结果LDL—C低水平组严重心血管事件发生率较正常组低（χ^2=4．68，P〈0．05），而较低水平组与极低水平组相比，差异无统计学意义（χ^2=0．06，P〉0．05）。结论〈2．07mmol／L的LDL—C低水平对严重心血管事件的发生率无明显影响。

Objective To explore the relationship of lower - level low density lipoprotein （ LDL - C ） after using statins with the incidence rate of serious cardiovascular events in patients with acute coronary syndrome. Methods 115 patients who had acute coronary syndrome（ acute myocardial infarction and unstable angina/non-ST elevation myocardial infarction） and were treated with PCI received statins and other drugs, they were devided into two groups. According to the level of low density lipoprotein, the LDL - C level in normal group was from 2. 07 to 3.36 mmol/L,while that in lower group was less than 2.07 mmol/L. Secendly,the lower group was devided into two groups, the first group was from 1.55 to 2. 07 mmol/L, the second group was less than 1.55 mmol/L. Results The incidence rate of serious cardiovascular events is lower in the lower group than that in the normal （ χ^2 = 4. 68, P 〈 0. 05 ）. But the incidence rates of first group and the second were significantly different （ χ^2 =0. 01 , P 〉 0. 05 ）. Conclusion Lower - lever low density lipoprotein doesn＇t increase the rate of serious cardiovascular events.