山茱萸对糖尿病小鼠血糖和组织糖原含量的影响

Effects of Frutus Corni on Bloob Sugar and Tissue Glycogen in Diabetic Mice

目的：观察山茱萸对血糖和组织糖原的影响。方法：采用四氧嘧啶建立糖尿病小鼠模型，并以优降糖作为阳性药物对照，用不同剂量山茱萸灌胃治疗，连续２１天后测定各组小鼠血糖和组织糖原含量。结果：①血糖：山茱萸中、大剂量二组血糖均显著低于对照组（Ｐ＜０．００１），但大剂量与中剂量组间以及与优降糖组无显著性差异（Ｐ＞０．０５）。②肝糖原含量：山茱萸各剂量组与对照组无显著性差异（Ｐ＞０．０５），而优降糖组显著高于对照组（Ｐ＜０．０１）。③心肌糖原含量：山茱萸大、小剂量组显著低于对照组（Ｐ＜０．０５），而山茱萸中剂量组和优降糖与对照组无显著差异（Ｐ＞０．０５）。结论：山茱萸发挥抗糖尿病作用需要较大剂量，但效力仍低于优降糖。

Objective To observe the effects of Fructus Corni (FC) on blood sugar and tissue glycogen in diabetic mice.Method The diabetes model was established by using alloxan and treated with different doses of FC through stomach tube for a periode of continued 21 days,while the control group was treated with glibenclamide.Then the blood sugar and tissue glycogen were measured.Results.①The blood sugar in middle and high FC dosage groups were significantly lower than that in control group (P<0.001),but there was no significant difference among the middle FC,high FC and glibenclamide groups (P>0.05). ②There was no significant difference about hepatic glycogen content between the various FC groups and control group(P>0.05),but that contentin glibenclamide group was significantly higher than that in control(P<0.01).③The myocardiac glycogen content in low and high FC groups were lower than that in control group(P<0.05), but there was no significant difference among the middle FC,glibenclamide and control groups(P>0.05).Conclusion:The massive dose of FC may be showed an anti-diabetic effect,but its efficiency is still less than that of glibenclamide.