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CD14^+-内皮祖细胞数量与冠心病及危险因素的相关性研究

Level of CD14^+-endothelial progenitor cells inversely correlates with body mass index
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摘要 目的探索CD14+-EPCs内皮祖细胞数量与冠心病(CAD)及心血管危险因素的关系。方法 100例患者入选,其中对照组34例,稳定性CAD组41例,急性冠脉综合征组25例,CD14+-EPCs定义为表面标记CD14+和KDR+细胞,用流式细胞仪检测其数量。结果三组间CD14+-EPCs水平没有显著差异;CD14+-EPCs数量与冠脉严重程度或传统危险因素也无关,但与体重指数(BMI)负相关。结论 CD14+-EPCs水平与CAD严重程度或传统心血管危险因素无关,但与BMI负相关。 Objective To investigate whether the number of circulating CD14+-EPCs correlate with both CAD and cardiovascular risk factors.Methods CD14^+-EPCs of 100 subjects including 34 control subjects,41 patients with stable CAD and 25 patients with acute coronary syndromes(ACS) were defined by the surface markers CD14+KDR+ and analyzed by flow cytometry.Results The level of circulating CD14^+-EPCs in patients with normal coronary artery was not significantly different from those with stable CAD or ACS.The number of circulating CD14^+-EPCs was not e associated with major cardiovascular risk factors too.The number of CD14^+KDR^+ cells was inversely correlated with BMI.Conclusions The number of circulating CD14^+-EPCs was not significantly correlated with the severity of coronary disease and traditional cardiovascular risk factors,but inversely correlated with BMI.
出处 《西部医学》 2010年第12期2195-2197,共3页 Medical Journal of West China
基金 绵阳市卫生局科研基金资助(编号:2008-8)
关键词 内皮祖细胞 冠状动脉疾病 危险因素 体重指数 Endothelial progenitor cells Coronary disease Risk factors Body mass index
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