CD14^+-内皮祖细胞数量与冠心病及危险因素的相关性研究

Level of CD14^+-endothelial progenitor cells inversely correlates with body mass index

目的探索CD14+-EPCs内皮祖细胞数量与冠心病(CAD)及心血管危险因素的关系。方法 100例患者入选,其中对照组34例,稳定性CAD组41例,急性冠脉综合征组25例,CD14+-EPCs定义为表面标记CD14+和KDR+细胞,用流式细胞仪检测其数量。结果三组间CD14+-EPCs水平没有显著差异;CD14+-EPCs数量与冠脉严重程度或传统危险因素也无关,但与体重指数(BMI)负相关。结论 CD14+-EPCs水平与CAD严重程度或传统心血管危险因素无关,但与BMI负相关。

Objective To investigate whether the number of circulating CD14＋-EPCs correlate with both CAD and cardiovascular risk factors.Methods CD14^＋-EPCs of 100 subjects including 34 control subjects,41 patients with stable CAD and 25 patients with acute coronary syndromes（ACS） were defined by the surface markers CD14＋KDR＋ and analyzed by flow cytometry.Results The level of circulating CD14^＋-EPCs in patients with normal coronary artery was not significantly different from those with stable CAD or ACS.The number of circulating CD14^＋-EPCs was not e associated with major cardiovascular risk factors too.The number of CD14^＋KDR^＋ cells was inversely correlated with BMI.Conclusions The number of circulating CD14^＋-EPCs was not significantly correlated with the severity of coronary disease and traditional cardiovascular risk factors,but inversely correlated with BMI.