甘精胰岛素在精神病合并糖尿病患者中的临床应用

Clinical use of insulin glargine for patients with psychosis plus diabetes

目的探讨甘精胰岛素在精神病合并糖尿病患者治疗中的疗效。方法 80例精神病合并糖尿病患者随机分为甘精胰岛素治疗组(A组)39例,常规胰岛素治疗组(B组)41例。观察两组患者治疗前后血糖变化、血糖调整时间、胰岛素用量、低血糖发生率。结果两组治疗后血糖均明显低于治疗前,A组能明显缩短调整期及治疗期的治疗时间(P<0.01),胰岛素用量少于B组(P<0.01),且低血糖发生率明显低于B组(P<0.05)。两组治疗后血糖无明显差异(P>0.05)。结论甘精胰岛素能迅速、有效、平稳地控制精神病合并糖尿病患者的血糖,不失为精神病合并糖尿病控制血糖的良好方法。

Objective To determine the therapeutic effect of insulin glargine patients with psychosis plus diabetes.Methods 80 psychosis patients with diabetes were treated with insulin glargine（A group,n=39）,multiple subcutaneous insulin injection（B group,n=41）.The blood glucose,the regulation period,insulin dose and the incidence rate of hypoglycemia were observed.Results The levels of blood glucose in both groups were reduced after the treatments.The regulation period and the course of A group treatment were shorter（P0.01） and the dosage of insuline was lower than that in B group（P0.01）.The incidence rate of hypoglycemia in A group was significantly lower than that in B group（P0.01）,but It is similar with both group blood glucose（P0.05）.Conclusion Insulin glargine can rapidly and stably controlblood glucose in patients with psychosis plus diabetes,and it is an ideal method for the control of serum glucose level in patients with psychosis plus diabetes.