P^(53)和P^(16)基因蛋白在软骨肉瘤中表达及其意义

The Expressions of P53 and P16 Tumor Suppressor Gene Proteins in Chondrsarcoma

目的：为探讨抑癌基因p53和p16在软骨肉瘤发生发展中的作用以及基因蛋白检测对软骨肉瘤分级和预后判断的意义。方法：用免疫组化SP法检测p53和p16基因蛋白产物在21例软骨肉瘤中表达并分析其与肿瘤病理分级的关系。结果：p53过渡表达和p16阳性率分别为57．1％、19．0％,p53阳性率与软骨肉瘤的恶性程度具有相关性（P＜0．05）。p16缺失和p53突变在软骨肉瘤中有协同表达。结论：p53和p16抑癌基因在软骨肉瘤发生、发展中具有重要作用，其基因蛋白对检测肿瘤恶性程度判断具有积极临床意义。

obective: To probe the functions of p53 and p16 tumor suppressor genes in carcinogenesis ofchondrosarcoma, and the significance of detecting protein products of p53 and p16 genes in the Pathological grades of chondrosarcoma and in the prognosis judgement. Methods By S - P Immunohistochemistrical tech -nique, the expressions of p53 and p16 gene proteins in 21 cases of chondrosarcoma were detected and the rela-tionship between their expressions and the Pathological grades of chondrosarcoma was analyzed. Results: Theghtive rates of p53 and p16 expressions were 57. 1 % and 19. 0% respectively, and the opitive rate of p53 ex- pression was related to the malignant degree of chondrosarcoma (P< 0. 05 ). p53 mutation and p16 deletion aboshowed co- expression in some of chondrosarcomas. Conclusions: p53 and p16 genes maybe play the importantroles in carciopness of chondrmrcoma, the detection of beth gene proteias has a positive significance in judg-ing the malignant degree of chondrosarcoma.