转化生长因子β在胃癌细胞内的表达

TRANSFORMING GROWTH FACTOR β EXPRESSION IN THE GASTRIC CANCER CELLS

目的：观察胃癌细胞内转化生长因子（ＴＧＦ）β的表达情况，探讨胃癌发展过程中ＴＧＦβ的可能作用。方法：４２例经胃镜活检、病理检查证实为胃癌。４４例浅表性胃炎的活检组织，采用免疫细胞化学方法—ＳＰ法显示ＴＧＦβ１及β２，其表达强度采用等级表示（由弱到强依次为－、±、＋、＋＋、＋＋＋）。结果：在４２例胃癌患者，ＴＧＦβ１无１例强阳性（＋＋＋），中度阳性（＋＋）１例，低度阳性（＋）１０例，可疑阳性（±）３例，阴性（－）２８例，阳性率为２６．２％。ＴＧＦβ２强阳性（＋＋＋）５例，中度阳性（＋＋）１６例，低度阳性（＋）１３例，可疑阳性（±）２例，阴性（－）６例；阳性率为８１．０％。４４例浅表性胃炎患者，ＴＧＦβ１无１例阳性（＋～＋＋＋），可疑阳性（±）４例，阴性（－）４０例。ＴＧＦβ２无１例中度阳性及强阳性（＋＋～＋＋＋），低度阳性（＋）１０例，可疑阳性（±）１例，阴性（－）３３例；阳性率为２２．７％。胃癌患者的ＴＧＦβ１、β２阳性率均明显高于浅表性胃炎，ＴＧＦβ２的阳性率在胃癌更高于ＴＧＦβ１。结论：ＴＧＦβ１，尤其是ＴＧＦβ２表达的增强是胃癌恶性演变的一个标志。

Taking immunological cytochemical method,transforming growth factor (TGF) β 1 and β 2 expression in the gastric cancer cells were observed among 42 cases.The results showed that TGF β 1 and β 2 expression was intensified,especially TGFβ 2.The positive rates of TGF β 1 and β 2 was 26.2% and 81.0% respectively among 42 cases,being obviously higher as comparing with 0.0% and 22.7% of total positive rate in superficial gastritis among 44 cases.This paper speculated that the increase of TGFβ 1 and β 2 expression in the gastric cancer cell may be an independent cellular marker in gastric cancer evolvement.