均匀试验设计优化聚β-环糊精包合丁香油的研究

Optimization of inclusion technology for clove oil with β-cyclodextrin polymer microsphere by uniform design

目的研究聚β-环糊精(β-CDP)微球包合丁香油的最佳工艺。方法采用饱和水溶液法制备丁香油β-CDP微球包合物,通过均匀试验设计对制备工艺进行了优化,并对包合物进行表征。结果最佳包合工艺条件是丁香油(mL)∶β-CDP微球(g)为1∶1,包合温度为35℃,包合时间为1 h,乙醇可忽略。结果显示丁香油能成功地被β-CDP微球包合。结论丁香油聚β-环糊精包合物包合得率更高,包合方法可行。

Objective To study the optimized technology of inclusion for the volatile oil of Caryophylli Flos with β-cyclodextrin polymer（β-CDP） microsphere.Methods β-CDP Microsphere was prepared by saturated peroxide solution.The study was carried out with uniform design to optimize the best inclusion processing conditions and inclusion compound was to characterize its structure.Results The best condition of the optimized technology of inclusion for the volatile oil of Caryophylli Flos with β-CDP microsphene was as follow： the volatile oil of Caryophylli Flos（mL）-β-CDP microsphere（g） was 1∶1;inclusion temperature was 35 ℃;clathration time was 1 h;ethyl alcohol could be ignored.The package method is successful by characterizing structure.Conclusion The inclusion compound of β-CDP has high rate and the inclusion process is reasonable and feasible.