不同感染途径对慢性丙型肝炎干扰素α-2b联合利巴韦林疗效的影响

The influences of different infection pathways on the effects of Interferon α-2b combined with Ribavirin treatment in patients with chronic hepatitis C infection

观察干扰素α-2b联合利巴韦林治疗不同途径感染的慢性丙型肝炎的疗效。对154例慢性丙型肝炎患者根据感染途径不同分为三组,进行干扰素α-2b联合利巴韦林治疗24周,在治疗24周结束和完成24周随访后,检测患者ALT和HCV-RNA定量水平,以生化应答率、病毒学应答率作为主要的评价指标,以复发率作为次要观察指标。治疗结束时,输血感染组、密切接触感染组和不明原因感染组生化应答率分别为77.27%,69.44%,54.17%;病毒应答指标中SVR分别为45.45%,47.23%,25%;NR分别为5.68%,8.33%,20.83%。治疗结束随访24周后,三组复发率分别为70.97%,68.00%,46.15%。结果表明,在干扰素α-2b联合利巴韦林治疗慢性丙型肝炎的疗效观察中,感染途径主要影响其生化应答和持续的病毒应答,甚至也影响治疗后的复发率。

To observe the effects of interferonα-2b combined with ribavirin treatment in patients with chronic hepatitis C infection in different infection pathways.According to the different infection pathways,154 cases of chronic hepatitis C patients were divided into three groups,treated with interferonα-2b combined with ribavirin for 24 weeks.At the end of24 weeks of treatment and after the 24 weeks of following-up,we detected the quantitative levels of patients’ALTand HCV-RNA,measured by rates of biochemical response and viral response as the main evaluation indicators,and the recurrence rate as a secondary index.At the end of treatment,in the three groups,which were the group infected with blood transfusion,close contaction and unknown reasons,the rates of biochemical response were 77.27%,69.44%,54.17%,the SVR of virus response were 45.45%,47.23%,25%,and the NR was 5.68%,8.33%,20.83%,respectively;After 24 weeks of following-up,the recurrence rates of the three groups were 70.97%,68.00% and 46.15%.The results showed that infection pathways mainly affected the biochemical response,the sustained viral response,and even the relapse rate after treatment,in patients with chronic hepatitis C infection which were treated with interferonα-2b combined with ribavirin.