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流行性乙型脑炎患儿IL-18的检测及意义 被引量：2

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摘要 目的:检测流行性乙型脑炎(乙脑)患儿血清及脑脊液(CSF)中白细胞介素-18(IL-18)水平,以探讨其乙脑发病机制中的作用。方法:总共收集到62份乙脑患儿极期(普通型20例、重型26例、极重型16例)、47份恢复期(普通型20例、重型21例、极重型6例)血清标本,50份极期(普通型18例、重型20例、极重型12例)、31份恢复期(普通型15例、重型12例、极重型4例)CSF标本,和20份对照组血清及CSF标本,用ELISA法检测其血清及CSF中IL-18水平。结果:3组患儿极期血清和CSF中IL-18水平均显著高于对照组(P<0.001),极重型最高,依次为重型、普通型,3组间两两比较差异有统计学意义(P<0.001);死亡组患儿(6例)极期血清中IL-18水平显著高于存活组(56例)(P<0.01),3组患儿极期血清和CSF中IL-18水平均显著高于恢复期(P<0.001),3组恢复期血清中IL-18水平与对照组比较差异均无统计学意义(P>0.05);3组恢复期CSF中IL-18水平均高于对照组,普通型与对照组、普通型与重型两两比较差异无统计学意义(P>0.05),重型显著高于对照组(P<0.05),极重型显著高于重型、普通型(P<0.001)。结论:动态检测乙脑患儿血清和CSF中IL-18水平有助于判断病情和预后,恢复期CSF中IL-18水平比血清水平更能反映颅内病变。
作者 张武英 冯冰 龙列明
机构地区 广东医学院附属医院感染内科
出处 《中国医药导报》 CAS 2010年第34期71-72,共2页 China Medical Herald
关键词 流行性乙型脑炎 白细胞介素-18 血清 脑脊液
分类号 R512.62 [医药卫生—内科学]
  • 相关文献

参考文献8

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共引文献13

同被引文献26

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引证文献2

二级引证文献15

中国医药导报
2010年 第34期

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