泮托拉唑隔日维持治疗内镜阴性胃食管反流病的疗效

Clinical effect of pantoprazole sodium maintenance treatment every other day dose on non-erosive reflux disease

目的评价泮托拉唑钠肠溶胶囊隔日维持治疗对内镜阴性胃食管反流病的疗效。方法 2008年3月-2010年3月,我院就诊的67例内镜阴性胃食管反流病患者,2个月基础治疗后,随机分为2组:隔日治疗组32例,常规治疗组35例。隔日治疗组隔日早餐前口服泮托拉唑钠肠溶胶囊40mg,常规治疗组每日早餐前口服泮托拉唑钠肠溶胶囊40mg。总观察时间为4个月,所有患者在治疗前及治疗后2、4个月进行反流性疾病问卷调查。结果两组患者第2个月RDQ评分比治疗前少(P<0.05),而第4个月RDQ评分与第2个月RDQ评分比较,差异无统计学意义(P>0.05)。两组RDQ评分比较,差异无统计学意义(P>0.05)。结论泮托拉唑钠肠溶胶囊隔日维持治疗可作为内镜阴性胃食管反流病维持治疗的手段。

Objective To explore the effect of pantoprazole sodium maintenance treatment every other day dose on non-erosive reflux disease（NERD）.Methods 67 patients with NERD were checked in our hospital from March 2008 to March 2010,they were randomly allocated to two groups after 2 months of foundation treatment.32 patients were treated with pantoprazole sodium maintenance treatment every other day dose,and 35 patients were treated with pantoprazole sodium maintenance treatment every day dose,the total viewing time was 4 months,RDQ scores of all patients before and after 2,4 months treatment were observed.Results RDQ scores of two groups after 2 months were smaller（P0.05）,but there was no significant difference between RDQ scores of 4th month and 2nd month（P0.05）,and the RDQ scores of two groups had no significant difference（P0.05）.Conclusion Every other day maintenance treatment of pantoprazole 40 mg is an effective management of NERD.