普鲁卡因青霉素治疗早期梅毒的疗效

Effect of procaine benzylpenicillin on early syphilis

目的分析普鲁卡因青霉素治疗早期梅毒的疗效。方法回顾分析我科应用普鲁卡因青霉素(80万U/d,肌肉注射,1次/d,连续15d)治疗26例早期梅毒患者的临床及血清学疗效。结果普鲁卡因青霉素治疗后1个月,24例显性梅毒患者均临床治愈。2年随访结束时,88.46%的患者达到血清学治愈(23/26);11.54%的患者为血清学固定(3/26)。一期梅毒TRUST滴度在治疗后3个月内下降最显著(P<0.01);二期梅毒TRUST滴度在治疗后9个月内明显下降(P<0.05),其中以治疗后6个月内下降最显著(P<0.01)。结论普鲁卡因青霉素治疗早期梅毒有效。

Objective To study the effect of procaine benzylpenicillin on early syphilis.Methods 26 patients with early syphilis who were treated with procaine benzylpenicillin（0.8 million units im daily for 15 days）were retrospectively analyzed.Results 24 dominant syphilis were cured in clinical manifestations after 1 month treatment of procaine benzylpenicillin.The serological treatment success rate was 88.46%（23/26）while the serum-resistance rate was 11.54%（3/26）after 24 months.TRUST titer of primary syphilis decreased significantly in 3 months after treatment（P0.01）,while TRUST titer of secondary syphilis decreased in 9 months after treatment（P0.05）,especially in 6 months after treatment（P0.01）.Conclusion Procaine benzylpenicillin is effective in treating early syphilis.