偏头痛患者血浆一氧化氮和降钙素基因相关肽含量测定及发病机制探讨

Nitric oxide and calcitonin gene related peptide contents in human being during migraine attack, and their possible pathogenetic investigation

目的探讨一氧化氮（ＮＯ）和降钙素基因相关肽（ＣＧＲＰ）在偏头痛发病机制中的作用。方法采用分光光度法和放免法，对偏头痛发作期２６例、间歇期２３例，其他头痛患者２７例及正常人２０例颈静脉（ＥＪＶ）和肘静脉（ＣＦ）血中ＮＯ和ＣＧＲＰ进行了测定。结果偏头痛发作组ＥＪＶ和ＣＦ血中ＮＯ含量均较正常人显著升高（Ｐ均＜０．０１）；偏头痛发作组ＥＪＶ血中ＣＧＲＰ含量明显升高（Ｐ＜０．０１），而ＣＦ血中两组间无显著差异（Ｐ＞０．０５）。结论ＮＯ和ＣＧＲＰ在偏头痛的发病机制中起重要作用。

Objective To investigate the pathogenetic role of nitric oxide(NO) and calcitonin gene related peptide(CGRP) in migraine. Methods Plasma NO was measured by spectrophotometry and CGRP was assayed by RIA from 26 patients with migraine during attack, 23 patients with migraine at intervals, 27 patients with other types of headache and 20 normal controls, blood was withdrawn from both external jugular vein (EJV) and cubital fossa (CF). Results Content of NO in both EJV and CF in migraine attack group was significantly higher than that in control group( P <0.01). The level of CGRP in EJV in migraine attack group was significantly higher than that in the other three groups( P <0.01), and there were no statistical differences in the level in CF among groups. Conclusion NO and CGRP may play an important role in the pathogenesis of migraine.