金黄色葡萄球菌药敏结果分析

DRUG SENSITIVITY TEST IN STAPHYLOCOCCUS AUREUS

目的了解我院金黄色葡萄球菌的分布及药敏情况,为金黄色葡萄球菌感染的治疗选药提供依据。方法对病人标本中分离出的308株金黄色葡萄球菌结合临床资料进行分析;按照CLSI标准判断金黄色葡萄球菌对抗生素的耐药性并测定耐甲氧西林金黄色葡萄球菌(MRSA)耐药情况。结果金黄色葡萄球菌对常用抗生素耐药率依次为青霉素98.1%,红霉素91.2%,克林霉素77.6%,庆大霉素75.6%,对万古霉素、替考拉宁和利奈唑胺的敏感率达100%;MRSA的检出率为74.0%。结论治疗金黄色葡萄球菌引起的感染,应根据药敏结果选用适宜的抗菌药物。

Objective To investigate the distribution and drug sensitivity of staphylococcus aureus （SA） in our hospital and provide an evidence for drug-choosing in the treatment of SA infection. Methods From samples of patients, 308 strains of SA were isolated and analyzed combined with clinical records. According to CLSI standard, the drug resistance of SA to antibiotics was identified and the phenotype of methicillin resistant staphylococcus aureus （MRSA） determined. Results The resistance rates of SA to commonly used antibiotics were in order of penicillin （98.1%）, erythromyein （91.2%）, clindamycin （77.6 %）, and gentamicin （75.6%） ; to vancomycin, teicoplanin and linezolid, the sensitiveness was 100%. The detection rate of MRSA was 74.00/60. Conclusion The antibiotics to be used for the therapy of infection caused by SA should be properly selected based on drug sensitivity test.