颈动脉内膜-中层厚度和血清炎症因子与冠心病关系

ASSOCIATION OF CORONARY ARTERY DISEASE WITH INTIMA-MEDIA THICKNESS OF THE COMMON CAROTID ARTERY AND INFLAMMATORY CYTOKINES

目的探讨颈动脉内膜-中层厚度(IMT)和血清炎症因子与冠心病的关系。方法测定了11例冠状动脉正常者和44例冠心病病人颈动脉IMT和血清白细胞介素(IL)-6、IL-8、IL-10浓度,全部对象均行冠状动脉造影检查。结果冠心病病人颈动脉IMT为(1.07±0.48)mm,冠状动脉正常者为(0.63±0.32)mm,两组比较差异有显著性(t=2.92,P<0.01)。冠心病病人血清IL-6、IL-8、IL-10的浓度分别为(112.61±14.94)ng/L、(0.50±0.11)μg/L、(300.79±35.73)ng/L,冠状动脉正常者分别为(89.36±7.90)ng/L、(0.34±0.13)μg/L、(243.58±60.71)ng/L,冠心病病人血清IL-6、IL-8、IL-10浓度高于冠状动脉正常者(t=3.00～4.97,P<0.05)。结论颈动脉IMT及血清IL-6、IL-8、IL-10浓度是心血管疾病强有力的预测因素。

Objective To study the association of coronary artery disease （CAD） with intima media thickness （IMT） of the common carotid artery and serum inflammatory cytokines. Methods IMT of the common carotid artery and serum levels of interleukin-6, 8,and 10 （IL-6, 8, 10） were detected in 11 people with normal coronary artery and 44 patients with CAD. All subjects studied underwent coronary artery angiograpby （CAG）. Results The IMT of the common carotid artery in patients with CAD was （1.07±0.48） mm, while that of normal subjects was （0.63±0.32） mm. The difference in IMT between the two groups was statistically significant （t=2.92,P〈0.01）. The serum levels of IL-6, 8, and 10 in CAD patients were （112. 61±14. 94） ng/ L, （0. 50±0.11） μg/L, and （300.79±35.73） ng/L, respectively, which were significantly higher than those of people with normal coronary artery （t=3.00-4.97,P〈0.05）, whose serum levels of IL-6, 8, and 10 were （89.36±7.90） ng/L, （0.34±0.13） μg/L, and （243.58±60.71） ng/L, respectively. Conclusion Intima-media thickness of the common carotid artery and serum levels of IL-6, 8, and 10 are important factors for predicting CAD.